Virtual power plant (VPP) serves as an effective solution for maintaining internal power balance and participating in external peak shaving auxiliary services within grid-connected microgrid involved in multi-type flexible resources (FRs). However, with increasing prominence of the feature heterogeneity in response behaviors of diverse FRs and their coupling in peak shaving poses challenges in the accurate decomposition of VPP scheduling commands. This paper proposes a de-aggregation strategy, utilizing discrete choice model and feature matching methods, to dynamically sequence FRs responses while optimizing VPP's peak shaving capability. Initially, heterogeneous features are refined and modeled to characterize the response capability of multi-type FRs in meeting the scheduled demand of grid-connected microgrid (SDGM). Subsequently, a feature difference quantification model and matching priority criterion are formulated to describe the feature mapping relationship and guide dynamic decision-making process. On this basis, the multi-type FRs are co-scheduled in the considered VPP to form a dynamic response sequence achieving peak shaving objectives. Case studies based on real data from a region-connected microgrid demonstrate the proposed strategy's performance in improving return on investment by 6.1 %, reducing peak shaving deviation and power exchange with main grid by 70 % and 13.1 %, respectively, and effectively improve the ability of grid-connected microgrid to balance the power and participate in peaking auxiliary services.

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Human longevity is heritable, but genome-wide association (GWA) studies have had limitedsuccess. Here, we perform two meta-analyses of GWA studies of a rigorous longevityphenotype definition including 11,262/3484 cases surviving at or beyond the age corre-sponding to the 90th/99th survival percentile, respectively, and 25,483 controls whose ageat death or at last contact was at or below the age corresponding to the 60th survivalpercentile. Consistent with previous reports, rs429358 (apolipoprotein E (ApoE)ε4) isassociated with lower odds of surviving to the 90th and 99th percentile age, while rs7412(ApoEε2) shows the opposite. Moreover, rs7676745, located nearGPR78, associates withlower odds of surviving to the 90th percentile age. Gene-level association analysis reveals arole for tissue-specific expression of multiple genes in longevity. Finally, genetic correlation ofthe longevity GWA results with that of several disease-related phenotypes points to a sharedgenetic architecture between health and longevity@en

Global water security is a severe issue that threatens human health and well-being. Finding sustainable alternative water resources has become a matter of great urgency. For coastal urban areas, desalinated seawater could serve as a freshwater supply. However, since 20%–30% of the water supply is used for flushing waste from the city, seawater with simple treatment could also partly replace the use of freshwater. In this work, the freshwater saving potential and environmental impacts of the urban water system (water-wastewater closed loop) adopting seawater desalination, seawater for toilet flushing (SWTF), or reclaimed water for toilet flushing (RWTF) are compared with those of a conventional freshwater system, through a life-cycle assessment and sensitivity analysis. The potential applications of these processes are also assessed. The results support the environmental sustainability of the SWTF approach, but its potential application depends on the coastal distance and effective population density of a city. Developed coastal cities with an effective population density exceeding 3000 persons·km⁻² and located less than 30 km from the seashore (for the main pipe supplying seawater to the city) would benefit from applying SWTF, regardless of other impact parameters. By further applying the sulfate reduction, autotrophic denitrification, and nitrification integrated (SANI) process for wastewater treatment, the maximum distance from the seashore can be extended to 60 km. Considering that most modern urbanized cities fulfill these criteria, the next generation of water supply systems could consist of a freshwater supply coupled with a seawater supply for sustainable urban development.

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