We present a transdisciplinary perspective for multiple actors interested in disaster-risk-reduction strategies in inhabited volcanoes, based on the novel approach of complexity and collaborative research. Our reflection is based on an ongoing research process that puts into dialogue scientific knowledge and local knowledge from Andean campesino communities inhabiting the Doña Juana Volcano-Páramo in the Latin American tropics. These local communities have experienced historically complex social, economic, and environmental conflicts in their territories; currently, most of them live in the buffer zones of the National Natural Park Doña Juana-Cascabel, which is part of Colombia’s national system of natural protected areas. We address inhabited Andean volcanoes as complex systems, which combine multi-temporal and spatial processes that allow for the emergence of nonlinear and heterogeneous social and ecological interdependencies. By transgressing disciplinary boundaries, we see an opportunity for building horizontal dialogues with communities inhabiting active volcanoes, understanding resilience, and eventually developing situated and collaborative disaster-risk-reduction strategies. The resulting vision is proposed as a fundamental methodology in settings such as south-western Colombia, marked by convoluted social dwelling patterns, and unequal biosocial and socioeconomic histories. Detached from positivistic and victimising perspectives, we seek to build knowledge on the antecedents, inheritance, persistence, and preservation of systems, ultimately enabling response-abilities for decision-making. The motivations, knowledge, and self-organisation capacities of the volcano inhabitants bring about new possibilities of doing locally while thinking globally. The transdisciplinary research approach allows us to situate our exchanges with the local community, and envision future collaborative paths towards promoting community-oriented forms of appropriation and transformation of a volcanic lifeworld.