A flexible sensor with excellent pressure, temperature, and bending sensitivity is fabricated based on the conductive skeleton material with hierarchical porous structure. The conductive skeleton material is composed of carbon fibres (CFs) and multiwalled carbon nanotubes (MWCNTs), in which lay perpendicular to each other CFs are used as conductive frames, while MWCNTs are served as bridges to connect the CFs and increase the conductive network formation. Owing to the unique structure and the conductive materials, the as-prepared sensor exhibits a high-pressure sensing performance of 42.7 kPa (0–1 kPa), fast response, relaxation times of<100 ms, wide working range of 0–60 kPa, and high stability over more than 6000 cycles. Furthermore, the fabricated sensor presents a high thermal sensitivity of 2.46 °C⁻¹ between 30 and 40 °C, excellent bending sensitivity of 95.5 % rad⁻¹ in the working range of 0–180°, and great flexibility (over 1000 cycles), demonstrating its potential applications in multifunctional wearable electronics.