In this work, we introduce a new workflow to solve portfolio optimization problems on annealing platforms. We combine a classical preprocessing step with a modified unconstrained binary optimization (QUBO) model and evaluate it using simulated annealing (classical computer), digital annealing (Fujitsu’s Digital Annealing Unit), and quantum annealing (D-Wave Advantage). Starting from Markowitz’s theory on portfolio optimization, our classical preprocessing step finds the most promising assets within a set of possible assets to choose from. We then modify existing QUBO models for portfolio optimization, such that there are no limitations on the number of assets that can be invested in. Furthermore, our QUBO model enables an investor to also place an arbitrary amount of money into each asset. We apply this modified QUBO to the set of promising asset candidates we generated previously via classical preprocessing. A solution to our QUBO model contains information about what percentage of the whole available capital should be invested into which asset. For the evaluation, we have used publicly available real-world data sets of stocks of the New York Stock Exchange as well as common ETFs. Finally, we have compared the respective annealing results with randomly generated portfolios by using the return, variance, and diversification of the created portfolios as measures. The results show that our QUBO formulation is capable of creating well-diversified portfolios that respect certain criteria given by an investor, such as maximizing return, minimizing risk, or sticking to a certain budget.@en