DNA sequence alignment is a fundamental and computationally expensive operation in bioinformatics. Researchers have developed pre-alignment filters that effectively reduce the amount of data consumed by the alignment process by discarding locations that result in a poor match. However, the filtering operation itself is memory-intensive for which the conventional Von-Neumann architectures perform poorly. Therefore, recent designs advocate compute near memory (CNM) accelerators based on stacked DRAM and more exotic memory technologies such as racetrack memories (RTM). However, these designs only support small DNA reads of circa 100 nucleotides, referred to as short reads. This letter proposes a CNM system for handling both long and short reads. It introduces a novel data-placement solution that significantly increases parallelism and reduces overhead. Evaluation results show substantial reductions in execution time (1.32times1.32×) and energy consumption (50%), compared to the state-of-the-art.

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Identifying the boundary beyond which quantum machines provide a computational advantage over their classical counterparts is a crucial step in charting their usefulness. Gaussian boson sampling (GBS), in which photons are measured from a highly entangled Gaussian state, is a leading approach in pursuing quantum advantage. State-of-the-art GBS experiments that run in minutes would require 600 million years to simulate using the best preexisting classical algorithms. Here, we present faster classical GBS simulation methods, including speed and accuracy improvements to the calculation of loop hafnians. We test these on a ∼100,000-core supercomputer to emulate GBS experiments with up to 100 modes and up to 92 photons. This reduces the simulation time for state-of-the-art GBS experiments to several months, a nine–orders of magnitude improvement over previous estimates. Last, we introduce a distribution that is efficient to sample from classically and that passes a variety of GBS validation methods. @en

Integrated photonics will play a key role in quantum systems as they grow from few-qubit prototypes to tens of thousands of qubits. The underlying optical quantum technologies can only be realized through the integration of these components onto quantum photonic integrated circuits (QPICs) with accompanying electronics. In the last decade, remarkable advances in quantum photonic integration have enabled table-top experiments to be scaled down to prototype chips with improvements in efficiency, robustness, and key performance metrics. These advances have enabled integrated quantum photonic technologies combining up to 650 optical and electrical components onto a single chip that are capable of programmable quantum information processing, chip-to-chip networking, hybrid quantum system integration, and high-speed communications. In this roadmap article, we highlight the status, current and future challenges, and emerging technologies in several key research areas in integrated quantum photonics, including photonic platforms, quantum and classical light sources, quantum frequency conversion, integrated detectors, and applications in computing, communications, and sensing. With advances in materials, photonic design architectures, fabrication and integration processes, packaging, and testing and benchmarking, in the next decade we can expect a transition from single- and few-function prototypes to large-scale integration of multi-functional and reconfigurable devices that will have a transformative impact on quantum information science and engineering.

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