This article provides support in organizing and implementing novel concepts for enhancing safety on a cluster level of chemical plants. The paper elaborates the requirements for integrating Safety Management Systems of chemical plants situated within a so-called chemical cluster. Recommendations of existing Plant Safety Management System Codes of Good Practice are analyzed in relation to the needs of cluster chemical safety. The paper establishes comprehensive guidelines for gradually standardizing Plant Safety Management Systems through the design, the development and the installation of a Cluster Safety Management System within a group of chemical companies. A cluster organization framework is proposed and a scheme for continuously improving cluster and plant safety management via communication and cooperation at plant department level as well as at cluster level is suggested.