Considering public moral attitudes is a hallmark of the anticipatory governance of emerging biotechnologies, such as heritable human genome editing. However, such anticipatory governance often overlooks that future morality is open to change and that future generations may perform different moral assessments on the very biotechnologies we are trying to govern in the present. In this article, we identify an ‘anticipatory gap’ that has not been sufficiently addressed in the discussion on the public governance of heritable genome editing, namely, uncertainty about the moral visions of future generations about the emerging applications that we are currently attempting to govern now. This paper motivates the relevance of this anticipatory gap, identifying the challenges it generates and offering various recommendations so that moral uncertainty does not lead to governance paralysis with regard to human germline genome editing.@en

This chapter provides a theoretical lens on conceptual disruption. It offers a typology of conceptual disruption, discusses its relation to conceptual engineering, and sketches a programmatic view of the implications of conceptual disruption for the ethics of technology. We begin by distinguishing between three different kinds of conceptual disruptions: conceptual gaps, conceptual overlaps, and conceptual misalignments. Subsequently, we distinguish between different mechanisms of conceptual disruption, and two modes of conceptual change. We point out that disruptions may be induced by technology, but can also be triggered by intercultural exchanges. Conceptual disruptions frequently yield conceptual uncertainty and may call for conceptual and ethical inquiry. We argue that a useful approach to address conceptual disruptions is to engage in conceptual engineering. We outline what conceptual engineering involves and argue that discussions on conceptual disruption and conceptual engineering can benefit from closer integration. In closing, we discuss the relevance of studying conceptual disruption for technology ethics, and point to the promise of this line of research to innovate practical philosophy at large.@en