Despite the recent advances in artificial tissue and organ engineering, how to generate large size viable and functional complex organs still remains as a grand challenge for regenerative medicine. Three-dimensional bioprinting has demonstrated its advantages as one of the major methods in fabricating simple tissues, yet it still faces difficulties to generate vasculatures and preserve cell functions in complex organ production. Here, we overcome the limitations of conventional bioprinting systems by converting a six degree-of-freedom robotic arm into a bioprinter, therefore enables cell printing on 3D complex-shaped vascular scaffolds from all directions. We also developed an oil bath-based cell printing method to better preserve cell natural functions after printing. Together with a self-designed bioreactor and a repeated print-and-culture strategy, our bioprinting system is capable to generate vascularized, contractible, and long-term survived cardiac tissues. Such bioprinting strategy mimics the in vivo organ development process and presents a promising solution for in vitro fabrication of complex organs.

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Using the raw data from consumer-level RGB-D cameras as input, we propose a deep-learning-based approach to efficiently generate RGB-D images with completed information in high resolution. To process the input images in low resolution with missing regions, new operators for adaptive convolution are introduced in our deep-learning network that consists of three cascaded modules - the completion module, the refinement module, and the super-resolution module. The completion module is based on an architecture of encoder-decoder, where the features of input raw RGB-D will be automatically extracted by the encoding layers of a deep neural network. The decoding layers are applied to reconstruct the completed depth map, which is followed by a refinement module to sharpen the boundary of different regions. For the super-resolution module, we generate RGB-D images in high resolution by multiple layers for feature extraction and a layer for upsampling. Benefited from the adaptive convolution operators proposed in this article, our results outperform the existing deep-learning-based approaches for RGB-D image complete and super-resolution. As an end-to-end approach, high-fidelity RGB-D images can be generated efficiently at the rate of 22 frames/s. Note to Practitioners - With the development of consumer-level RGB-D cameras, industries have started to employ these low-cost sensors in many robotic and automation applications. However, images generated by consumer-level RGB-D cameras are generally in low resolution. Moreover, the depth images often have incomplete regions when the surface of an object is transparent, highly reflective, or beyond the distance of sensing. With the help of our method, engineers are able to 'repair' the images captured by consumer-level RGB-D cameras in high efficiency. As the typical deep-learning networks are employed in this approach, the proposed approach fits well with the GPU-based hardware architecture of deep-learning computation - therefore, it potentially can be integrated into the hardware of RGB-D cameras.

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The following sections are included: • Introduction • Literature Review • Direct Deposition: Our Study • Results • Electrical Conductivity • Discussion • Summary • Acknowledgment • References.

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We present a method for fabricating general models with multi-directional 3-D printing systems by printing different model regions along with different directions. The core of our method is a support-effective volume decomposition algorithm that minimizes the area of the regions with large overhangs. A beam-guided searching algorithm with manufacturing constraints determines the optimal volume decomposition, which is represented by a sequence of clipping planes. While current approaches require manually assembling separate components into a final model, our algorithm allows for directly printing the final model in a single pass. It can also be applied to models with loops and handles. A supplementary algorithm generates special supporting structures for models where supporting structures for large overhangs cannot be eliminated. We verify the effectiveness of our method using two hardware systems: a Cartesian-motion-based system and an angular-motion-based system. A variety of 3-D models have been successfully fabricated on these systems. Note to Practitioners - In conventional planar-layer-based 3-D printing systems, supporting structures need to be added at the bottom of large overhanging regions to prevent material collapse. Supporting structures used in single-material 3-D printing technologies have three major problems: being difficult to remove, introducing surface damage, and wasting material. This article introduces a method to improve 3-D printing by adding rotation during the manufacturing process. To keep the hardware system relatively inexpensive, the hardware, called a multi-directional 3-D printing system, only needs to provide unsynchronized rotations. In this system, models are subdivided into different regions, and then, the regions are printed in different directions. We develop a general volume decomposition algorithm for effectively reducing the area that needs supporting structures. When supporting structures cannot be eliminated, we provide a supplementary algorithm for generating supports compatible with multi-directional 3-D printing. Our method can speed up the process of 3-D printing by saving time in producing and removing supports.

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Additive manufacturing (AM) is causing a revolution in product design, manufacturing and distribution. This technology facilitates the production of complex, customized products without the need of any specific tooling, thereby enabling products to be delivered at a lower cost than with traditional manufacturing. From a design perspective, AM allows designers to selectively place (multi-)material where it is needed to achieve the designed functionality. However, despite remarkable progress in the domain of AM, a variety of challenges – like support structures, staircase effects, and mechanical performance [1] – should be investigated at depth to fully explore the potential of AM. On the other hand, these challenges limit the designers’ freedom to realize their creativity...@en

We present a method for effectively planning the motion trajectory of robots in manufacturing tasks, the tool paths of which are usually complex and have a large number of discrete time constraints as waypoints. Kinematic redundancy also exists in these robotic systems. The jerk of motion is optimized in our trajectory planning method at the meanwhile of fabrication process to improve the quality of fabrication. Our method is based on a sampling strategy and consists of two major parts. After determining an initial path by graph search, a greedy algorithm is adopted to optimize a path by locally applying adaptive filers in the regions with large jerks. The filtered result is obtained by numerical optimization. In order to achieve efficient computation, an adaptive sampling method is developed for learning a collision-indication function that is represented as a support-vector machine. Applications in robot-Assisted 3-D printing are given in this article to demonstrate the functionality of our approach. Note to Practitioners-In robot-Assisted manufacturing applications, robotic arms are employed to realize the motion of workpieces (or machining tools) specified as a sequence of waypoints with the positions of tool tip and the tool orientations constrained. The required degree of freedom (DOF) is often less than the robotic hardware system (e.g., a robotic arm has six-DOF). Specifically, rotations of the workpiece around the axis of a tool can be arbitrary (see Fig. 1 for an example). By using this redundancy, i.e., there are many possible poses of a robotic arm to realize a given waypoint, the trajectory of robots can be optimized to consider the performance of motion in velocity, acceleration, and jerk in the joint space. In addition, when fabricating complex models, each tool path can have a large amount of waypoints. It is crucial for a motion planning algorithm to compute a smooth and collision-free trajectory of robot to improve the fabrication quality. The time taken by the planning algorithm should not significantly lengthen the total manufacturing time; ideally, it would remain hidden as computing motions for a layer can be done while the previous layer is printing. The method presented in this article provides an efficient framework to tackle this problem. The framework has been well tested on our robot-Assisted additive manufacturing system to demonstrate its effectiveness and can be generally applied to other robot-Assisted manufacturing systems.

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This letter tackles the problem of energy-efficient coverage path planning for exploring general surfaces by an autonomous vehicle. Efficient algorithms are developed to generate paths on freeform 3-D surfaces according to a special design pattern as height extremity aware Fermat spiral for this purpose. By using the exact boundary-sourced geodesic distances, the method for generating Fermat spiral paths is first introduced to cover a general surface. Then, heuristics for energy efficiency are incorporated to add peak points of a height field as sources for geodesic computation. The paths generated by our method can significantly reduce the cost caused by gravity. Physical experiments have been taken on different terrain surfaces to demonstrate the effectiveness of our approach.

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This paper presents a new method to fabricate 3D models on a robotic printing system equipped with multi-axis motion. Materials are accumulated inside the volume along curved tool-paths so that the need of supporting structures can be tremendously reduced - if not completely abandoned - on all models. Our strategy to tackle the challenge of tool-path planning for multi-axis 3D printing is to perform two successive decompositions, first volume-to-surfaces and then surfaces-to-curves. The volume-to-surfaces decomposition is achieved by optimizing a scalar field within the volume that represents the fabrication sequence. The field is constrained such that its isovalues represent curved layers that are supported from below, and present a convex surface affording for collision-free navigation of the printer head. After extracting all curved layers, the surfaces-to-curves decomposition covers them with tool-paths while taking into account constraints from the robotic printing system. Our method successfully generates tool-paths for 3D printing models with large overhangs and high-genus topology. We fabricated several challenging cases on our robotic platform to verify and demonstrate its capabilities.

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This paper introduces a novel method for designing personalized orthopedic casts which are aware of thermal-comfort while satisfying mechanical requirements. Our pipeline starts from thermal images taken by an infrared camera, by which the distribution of thermal-comfort sensitivity is generated on the surface of a 3D scanned model. We formulate a hollowed Voronoi tessellation pattern to represent the covered region for a web-like cast design. The pattern is further optimized according to the thermal-comfort sensitivity calculated from thermal images. Working together with a thickness variation method, we generate a solid model for a personalized cast maximizing both thermal comfort and mechanical stiffness. To demonstrate the effectiveness of our approach, 3D printed models of personalized casts are tested on body parts of different individuals.@en

This paper presents a robotic system - RoboFDM that targets at printing 3D models without support-structures, which is considered as the major restriction to the flexibility of 3D printing. The hardware of RoboFDM consists of a robotic arm providing 6-DOF motion to the platform of material accumulation and an extruder forming molten filaments of polylactic acid (PLA). The fabrication of 3D models in this system follows the principle of fused decomposition modeling (FDM). Different from conventional FDM, an input model fabricated by RoboFDM is printed along different directions at different places. A new algorithm is developed to decompose models into support-free parts that can be printed one by one in a collision-free sequence. The printing directions of all parts are also determined during the computation of model decomposition. Experiments have been successfully taken on our RoboFDM system to print general freeform objects in a support-free manner.

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