This article proposes an output-feedback fixed-time trajectory tracking control methodology for hypersonic flight vehicles subject to asymmetric output constraints. In contrast to the state of the art, the most distinguishing feature of our control design lies in avoiding using conventional recursive design methods (e.g., backstepping technique, dynamic surface control, etc.) and in not relying on full-state availability. In the velocity control loop, an asymmetric integral barrier Lyapunov function is adopted to confine velocity variable within a well-defined compact set all the time. In the altitude control loop, after utilizing its cascaded property and proposing a novel scaling function, the original constrained system is transformed to an unconstrained one, which facilitates the control design and stability analysis. Moreover, the proposed control algorithm only involves one fuzzy logic approximator as well as one fixed-time differentiator in the transformed system and guarantees that the tracking errors of velocity and altitude converge into the user-defined residual sets within fixed time. Several comparative simulations have been conducted to highlight the superiorities of the developed method.