Growth-oriented Development in the Peruvian Amazonia commodifies its biocultural diversity. Thus, inscribed in a path dependence of unfulfilled promises of local development, the Amazon Waterway Project seeks to create an international trade chain connecting produce from Manaus in Brazil to China by dredging the four most important Peruvian Amazonian rivers. In such a complex territory, the execution of the Amazon Waterway Project represents both a risk of widening the territorial unevenness gap and a challenge for creating alternative development. In this regard, the research shows the relevance of spatial planning and design looking upon the talents, opportunities and knowledge of the territory to create new shared understandings for a holistic development. This would pursue social and ecological wellbeing by involving local and global agents, as well as reframing big scale infrastructure projects as integral development opportunities. The main goal is to build a cooperative relationship of Amazonian cities and communities. Therefore, a landscape economy strategy is envisioned at multiple scales as a start for a co-creation process. This includes a series of interventions, guides, protocols and dialogue spaces towards the construction of a New Amazon Pact.