This paper presents a comprehensive investigation of the swelling behaviour of a compacted bentonite–sand mixture subjected to hydration under constant volume conditions. Contrary to previous studies, the tested sample was isotropically compacted before being hydrated under constant volume conditions until full saturation was reached. The total axial pressure, total radial pressures at four different heights of the sample, and injected water volume were recorded over time. The experimental data reveal a complex and non-uniform evolution of the axial and radial stresses over time, as well as anisotropy of the total stresses, which persist at the saturated equilibrated state. To gain further insights, a numerical analysis was performed using an advanced hydromechanical framework for partially saturated porous media, accounting for the evolving microstructure of the material. The complex evolution of the total axial and radial pressures with time is attributed to the advancing hydration and swelling front in the sample, along with the development of irreversible strains. The good agreement between the numerical results and the experimental data enables validation of the developed framework. Implications for engineered barriers in deep geological disposal of radioactive waste are discussed.