In recent decades, increasing ultrasound frame rates has been the main motivation behind many novel ultrasound imaging applications [1]-[3]. With this work, we propose an efficient ultrafast FPGA beamformer that applies coherent compounding, through a delay-reuse optimization.

DNA read alignment is an integral part of genome study, which has been revolutionised thanks to the growth of Next Generation Sequencing (NGS) technologies. The inherent computational intensity of string matching algorithms such as Smith-Waterman (SmW) and the vast amount of NGS input data, create a bottleneck in the workflows. Accelerated reconfigurable computing has been extensively leveraged to alleviate this bottleneck, focusing on high-performance albeit standalone implementations. In existing accelerated solutions effective co-design of NGS short-read alignment still remains an open issue, mainly due to narrow view on real integration aspects, such as system wide communication and accelerator call overheads. In this paper, we first propose GANDAFL, a novel Genome AligNment DAta-FLow architecture for SmW Matrix-fill and Traceback stages to perform high throughput short-read alignment on NGS data. We then propose a radical software restructuring to widely-used Bowtie2 aligner that allows read alignment by batches to expose acceleration capabilities. Batch alignment minimizes calling overhead of the accelerators whereas moving both Matrix-fill and Traceback on chip extinguishes the communication data overheads. The standalone solution delivers up to ×116 and ×2 speedup over state-of-the-art software and hardware accelerators respectively and GANDAFL-enhanced Bowtie2 aligner delivers a ×1.9 speedup.

Mathematical models with varying degrees of complexity have been proposed and simulated in an attempt to represent the intricate mechanisms of the human neuron. One of the most biochemically realistic and analytical models, based on the Hodgkin–Huxley (HH) model, has been selected for study in this paper. In order to satisfy the model's computational demands, we present a simulator implemented on Intel Xeon Phi Knights Landing manycore processors. This high-performance platform features an x86-based architecture, allowing our implementation to be portable to other common manycore processing machines. This is reinforced by the fact that Phi adopts the popular OpenMP and MPI programming models. The simulator performance is evaluated when calculating neuronal networks of varying sizes, density and network connectivity maps. The evaluation leads to an analysis of the neuronal synaptic patterns and their impact on performance when tackling this type of workload on a multinode system. It will be shown that the simulator can calculate 100 ms of simulated brain activity for up to 2 millions of biophysically-accurate neurons and 2 billion neuronal synapses within one minute of execution time. This level of performance renders the application an efficient solution for large-scale detailed model simulation.

Ordinary Differential Equations (ODEs) are widely used in many high-performance computing applications. However, contemporary processors generally provide limited throughput for these kinds of calculations. A high-performance hardware accelerator has been developed for speeding-up the solution of ODEs. The hardware accelerator has been developed both for single and double floating-point precision types and a design-space exploration has been performed in terms of performance and hardware resources. The hardware accelerator has been mapped to an FPGA board and connected through PCIe to a typical processor. The performance evaluation shows that the proposed scheme can achieve up to 14x speedup compared to a reference, single-core CPU solution.