Human cognitive enhancement (HCE) is an area in which non-therapeutic enhancements have been widely debated. Some applications are already on the market and available for home use (e.g. non-invasive brain stimulation devices), while other forms of enhancement such as ‘smart drugs’ or pharmacological enhancers are readily available (albeit ‘off-label’ or illegally obtained). Private and public interest in HCE may well intensify as the field engages with broader societal trends such as an increasingly competitive work-life and greater demands for productivity, in addition to increased interest in cognitive enhancement more generally. There is thus a need for some dedicated and timely consideration of the area, particularly with regard to governance issues. Responsible Research and Innovation (RRI) offers one possible approach that aims to anticipate and reflect on potential implications and societal expectations with respect to research and innovation. This article takes up current work on the HCENAT (Naturalness in Human Cognitive Enhancement) project and offers some essential features of RRI for HCE.@en