This paper presents the results of using the Least-Squares Support Vector Machines (LS-SVMs) framework for estimating CO₂ levels at the Holst Center building in the Netherlands. Within the IoT framework, a Wireless Sensor Network (WSN) consisting of seven sensors is currently deployed at the third floor of the building. Each sensor node provides measures of temperature, relative humidity and CO₂ levels, and transmits the readings to a consumer accessible cloud. Given that CO₂ has a big impact on people comfort and productivity, its monitoring and control has become a common practice in recent years. In this work we provide a way to estimate the CO₂ concentration when a CO₂ sensor is not trustworthy (e.g., due to maintenance or a malfunction), by using nonlinear models built from historical sensor data. Results showed that the model structures proposed in this work provided better CO₂ estimates than those given by conventional linear autoregressive (AR) and autoregressive exogenous (ARX) models.

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Background
Discovering novel disease genes is still challenging for diseases for which no prior knowledge - such as known disease genes or disease-related pathways - is available. Performing genetic studies frequently results in large lists of candidate genes of which only few can be followed up for further investigation. We have recently developed a computational method for constitutional genetic disorders that identifies the most promising candidate genes by replacing prior knowledge by experimental data of differential gene expression between affected and healthy individuals.
To improve the performance of our prioritization strategy, we have extended our previous work by applying different machine learning approaches that identify promising candidate genes by determining whether a gene is surrounded by highly differentially expressed genes in a functional association or protein-protein interaction network.
Results
We have proposed three strategies scoring disease candidate genes relying on network-based machine learning approaches, such as kernel ridge regression, heat kernel, and Arnoldi kernel approximation. For comparison purposes, a local measure based on the expression of the direct neighbors is also computed. We have benchmarked these strategies on 40 publicly available knockout experiments in mice, and performance was assessed against results obtained using a standard procedure in genetics that ranks candidate genes based solely on their differential expression levels (Simple Expression Ranking). Our results showed that our four strategies could outperform this standard procedure and that the best results were obtained using the Heat Kernel Diffusion Ranking leading to an average ranking position of 8 out of 100 genes, an AUC value of 92.3% and an error reduction of 52.8% relative to the standard procedure approach which ranked the knockout gene on average at position 17 with an AUC value of 83.7%.
Conclusion
In this study we could identify promising candidate genes using network based machine learning approaches even if no knowledge is available about the disease or phenotype.
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