Sound-absorbing barriers and screens are commonly employed to mitigate one of the most annoying noises in workplaces: intelligible speech. However, isolating their acoustic contribution from all the other elements (ceilings, wall treatment, or carpets) is challenging. This study uses a wave-based room acoustic modeling approach to explore the acoustic function of desk screens in a virtually reconstructed open-plan office. Analytical models, finite-element simulations, and experimental data from 3D-printed samples allowed defining a multi-resonator unit cell, attenuating the voice signal's main formants. The sound-absorbing panels composed of the unit modules iteration are assessed in the full-scale digital model, starting from the calibrated version on in-field measurements. The wave-based engine employed in this study grants the crucial aspect of computing the acoustic performance of the potential multi-resonator screens, including the edge diffraction due to their desk installation. In the virtual workplace, the acoustic role of such screens in increasing the speech level decay is outlined in comparison with the calibrated scenario and the traditional screens' option.@en