JJ
Jeroen C. Jansen
2 records found
1
Fully Automated 3D Vestibular Schwannoma Segmentation with and without Gadolinium-based Contrast Material
A Multicenter, Multivendor Study
Purpose: To develop automated vestibular schwannoma measurements on contrast-enhanced T1-and T2-weighted MRI scans. Materials and Methods: MRI data from 214 patients in 37 different centers were retrospectively analyzed between 2020 and 2021. Patients with hearing loss (134 posit
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Parent-of-origin tumourigenesis is mediated by an essential imprinted modifier in SDHD-linked paragangliomas
SLC22A18 and CDKN1C are candidate tumour modifiers
Mutations in SDHD and SDHAF2 (both located on chromosome 11) give rise to hereditary paraganglioma almost exclusively after paternal transmission of the mutation, and tumours often show loss of the entire maternal copy of chromosome 11. The 'Hensen' model postulates that a tumour
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