Automated high-resolution sampling and multi-mode operando spectroscopy of (bio-)chemical reactions for kinetic analysis, reaction characterization, and quality control

Abstract

This invention describes an apparatus that enables the automated removal of small samples from fluids such as those encountered in (bio-)chemical reactors. These samples can then be used for, e.g., kinetic analysis and quality control applications. The system was explicitly designed to be compatible with harsh and aggressive reaction conditions and can be used up to 250°C and 345 bar. The system was incorporated into a high-pressure capable operando reaction analysis platform that enabled simultaneous sampling of the reaction mixture and operando monitoring of the reaction using multiple channels of spectroscopy, thereby offering accessible and convenient data-rich experimentation. We have started a company to further develop the technology and bring it to market. We are actively looking for early adopters, collaborators, joint-venturing, and investors.