Design of a molecular clock with RNA-mediated regulation

Blanchini, F.; Cuba Samaniego, Christian; Franco, Elisa; Giordano, Giulia

Design of a molecular clock with RNA-mediated regulation

Conference paper (2014)

Authors

F. Blanchini Università degli Studi di Udine

Christian Cuba Samaniego University of California

Elisa Franco University of California

Giulia Giordano Università degli Studi di Udine

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Published Date

01-01-2014

Language

English

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Abstract

We design a new negative feedback molecular oscillator and study its properties analytically and numerically. This oscillator is composed of two synthetic genes interconnected through their RNA outputs. Regulation of the genes activity is achieved by controlling the activity of the enzymes rather than the activity of the promoters. We show that a simple model of this system has the potential to oscillate for appropriate choices of the parameters. Our design can be built experimentally using RNA aptamers.