Injectable pH-responsive Ureido-Pyrimidinone (UPy) hydrogel as drug carrier for epicardial activation

Master thesis (2019)

Authors

F.C. Lauta Mechanical Engineering

Contributors

E.L. Fratila-Apachitei Biomaterials & Tissue Biomechanics - Mechanical, Maritime and Materials Engineering (mentor)
A.A. Zadpoor Biomaterials & Tissue Biomechanics - Mechanical, Maritime and Materials Engineering (graduation committee member)
M-J TH Goumans Leiden University Medical Center (graduation committee member)
Esther Dronkers Leiden University Medical Center (graduation committee member)
E.C.M. Carroll ImPhys/Charged Particle Optics (graduation committee member)
Faculty
Mechanical Engineering, Mechanical Engineering
Copyright: © 2019 Francesca Lauta
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Published Date

29-04-2019

Language

English

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Faculty

Mechanical Engineering

Abstract

The presence of a stem cell source in the epicardium that can be stimulated by exogenous delivery of transforming growth factor-β (TGF-β) and migrate towards the myocardium can represent a new approach to achieve cardiac repair following myocardial infarction. However, injection of drugs always requires use of carriers which help stabilize the compound in the harsh and dynamic environment of the heart. To this extent, pH-responsive drug delivery systems represent an enthralling approach to ensure minimal invasiveness, instantaneous responsiveness, and targeted delivery of the incorporated compound. In this in vitro study we aimed to validate an Ureidopyrimidinone-based supramolecular hydrogel as TGF-β carrier for epicardial activation. The results demonstrated the capacity of the hydrogel to respond to pH changes and deliver the growth factor, which retained its ability to activate its signalling pathway and stimulate treated cells.

Files

Thesis_FCLauta.pdf
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- Embargo expired in 30-04-2022