Computational design of patient-specific orthopedic implants

Garner, E.

doi:10.4233/bbd11d77-f64a-4498-a0b8-16975f6e1e77

Computational design of patient-specific orthopedic implants

from micro-architected materials to shape-matching geometry

Doctoral thesis (2024)

Authors

E. Garner Biomaterials & Tissue Biomechanics

Research Group

Biomaterials & Tissue Biomechanics

DOI: https://doi.org/10.4233/uuid:bbd11d77-f64a-4498-a0b8-16975f6e1e77

Topology optimization Computational design Patient-specific Orthopedic implants Micro-architected materials Bone remodelling Bone preservation Osseointegration Insertability

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Published Date

2024

Language

English

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Research Group

Biomaterials & Tissue Biomechanics

Abstract

Background: Despite over a century’s worth of technical improvements, the longterm survivability associated with orthopedic implants continues to fall short. In contrast to earlier designs, implant failure is no longer caused by structural failure of the implant itself. Rather, it results from the implant’s long-term detrimental effects on the surrounding bone tissue. Over time, changes in mechanical loading conditions induce a reduction in bone density, increasing the risk of fracture, and destabilizing the bone-implant interface. The mechanisms which drive peri-prosthetic bone loss are complicated and inter-related. Add to this the unique morphological variations among patients, and an optimal one-size-fits-all solution seems unlikely.....

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