Seeing with electrons

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Abstract

Transformative technological advances have propelled cryogenic electron microscopy (cryo-EM) to take center stage in elucidating the intricacies of the nanoscale molecular machinery of viruses, bacteria and eukaryotic cells. Continued developments hold exciting promise for structural biophysicists to move closer to their dream of visualising atomic resolution snapshots of individual molecules at work in their native cellular environment.

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