Novel genetic parts and cultivation strategies for yeast-based conversion of lignocellulosic feedstocks

Doctoral thesis (2018)

Authors

M.D. Verhoeven BT/Industriele Microbiologie -

Research Group

BT/Industriele Microbiologie () (TU Delft)

DOI: https://doi.org/10.4233/uuid:afd3a04b-1e86-4561-bc9e-87ad8e569de3

Biotechnology Xylose Saccharomyces cerevisiae Pentose fermentation Arabinose Yeast Lignocellulosic biofuels Ethanol

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Published Date

2018

Language

English

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Faculty

Applied Sciences

Department

BT/Biotechnologie

Research Group

BT/Industriele Microbiologie

Abstract

The recent start-up of several full-scale ‘second generation’ ethanol plants marks a major milestone in the development of Saccharomyces cerevisiae yeast strains for fermentation of lignocellulosic hydrolysates of agricultural residues and energy crops. In contrast to the fermentation of hexose sugar-rich substrates, such as corn syrup or sugar cane bagasse, these hydrolysates contain mixtures of the hexose sugar D-glucose and the pentose sugars D-xylose and L-arabinose. While S. cerevisiae performs excellently in fermenting hexose sugars to ethanol, efficient utilization of pentose sugars required extensive metabolic and evolutionary engineering.

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