Selective Peroxygenase-Catalysed Oxidation of Toluene Derivates to Benzaldehydes

Journal article (2023)

Authors

Y. Wang Tianjin University, BT/Biocatalysis - AS
Niklas Teetz University of Applied Sciences Mittelhessen
Dirk Holtmann University of Applied Sciences Mittelhessen
Miguel Alcalde Institute of Catalysis, CSIC, Madrid
J.M.A. van Hengst BT/Biocatalysis - AS
Xiaoxiao Liu Chinese Academy of Sciences
Mengfan Wang Tianjin University
Wei Qi Tianjin University
Wuyuan Zhang Chinese Academy of Sciences
F. Hollmann BT/Biocatalysis - AS
Research Group
BT/Biocatalysis (AS) (TU Delft)
Copyright: © 2023 Y. Wang, Niklas Teetz, Dirk Holtmann, Miguel Alcalde, J.M.A. van Hengst, Xiaoxiao Liu, Mengfan Wang, Wei Qi, Wuyuan Zhang, F. Hollmann
DOI: https://doi.org/10.1002/cctc.202300645
More Info
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Published Date

2023

Language

English

Faculty

Applied Sciences

Department

BT/Biotechnologie

Research Group

BT/Biocatalysis

Abstract

Biocatalytic oxidation reactions of toluene derivates to the corresponding aldehydes are typically challenged by regio- and chemoselectivity issues. In this contribution we address both challenges by a combined reactant- and reaction engineering approach. We demonstrate that the peroxygenase-catalysed transformation of ring-substituted toluenes proceeds highly regioselectively in benzylic position. Furthermore, neat reaction conditions not only enable attractive product concentrations (up to 185 mM) but also result in highly chemoselective oxidations to the aldehyde level.