Organ-on-Chip In Development

Towards a roadmap for Organs-on-Chip

Journal article (2019)

Authors

Massimo Mastrangeli Electronic Components, Technology and Materials - EEMCS
Sylvie Millet CEA Grenoble
Research Group
Electronic Components, Technology and Materials (EEMCS) (TU Delft)
Copyright: © 2019 Massimo Mastrangeli, Sylvie Millet, the ORCHID partners, Janny van den Eijnden-van Raaij
DOI: https://doi.org/10.14573/altex.1908271
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Published Date

24-10-2019

Language

English

Faculty

Electrical Engineering, Mathematics and Computer Science

Department

Microelectronics

Research Group

Electronic Components, Technology and Materials

Abstract

Organ-on-Chip is considered a potentially game-changing technology born from the convergence of tissue engineering and microfluidic technology. Organ-on-Chip devices (OoCs) are expected to offer effective solutions to persisting problems in drug development and personalized disease treatments. This opinion paper surveys the current landscape in research, development, application and market opportunities for OoCs towards establishing a global and multi-stakeholder OoC eco-system. Based on panel discussions held at the Vision Workshop (Stuttgart, 23 May 2018) organized by the EU ORCHID consortium, as well as on additional bibliometric study, market analysis and expert interviews conducted within the EU ORCHID project, we outline perceived unmet needs, key challenges, barriers and perspectives of the field. We finally propose recommendations to-wards the definition of a comprehensive roadmap that could render OoCs realistic models of hu-man (patho)physiology in the near future.