Theoretical analysis of coronary blood flow and tissue oxygen pressure-control

Book chapter (1993)

Authors

Jos A.E. Spaan Universiteit van Amsterdam
J. Dankelman Medical Instruments & Bio-Inspired Technology - Mechanical, Maritime and Materials Engineering
Research Group
Medical Instruments & Bio-Inspired Technology (Mechanical, Maritime and Materials Engineering) (TU Delft)
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Published Date

1993

Language

English

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Faculty

Mechanical, Maritime and Materials Engineering

Department

Biomechanical Engineering

Research Group

Medical Instruments & Bio-Inspired Technology

Abstract

Coronary blood flow is tightly coupled to the myocardial oxygen consumption. We have presented a control model based on the assumption that the tissue oxygen pressure is the controlled variable. The coronary blood flow in itself is not a controlled variable but merely the result of a different control system: the tissue oxygen pressure. From our control equation there is no relation between the slope of the autoregulation curve and the gain of the tissue P02 control system. The slope is independent of the level of oxygen consumption.