Aqueous chemoenzymatic one-pot enantioselective synthesis of tertiary α-aryl cycloketonesviaPd-catalyzed C-C formation and enzymatic C=C asymmetric hydrogenation

Journal article (2021)

Authors

Pengqian Luan Hebei University of Technology
Yunting Liu Hebei University of Technology, Tianjin University
Yongxing Li Hebei University of Technology
Ran Chen Hebei University of Technology
Chen Huang Hebei University of Technology
Jing Gao Hebei University of Technology
F. Hollmann BT/Biocatalysis - AS
Yanjun Jiang Hebei University of Technology
Research Group
BT/Biocatalysis (AS) (TU Delft)
Copyright: © 2021 Pengqian Luan, Yunting Liu, Yongxing Li, Ran Chen, Chen Huang, Jing Gao, F. Hollmann, Yanjun Jiang
DOI: https://doi.org/10.1039/d1gc00372k
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Published Date

2021

Language

English

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Faculty

Applied Sciences

Department

BT/Biotechnologie

Research Group

BT/Biocatalysis

Abstract

An aqueous chemoenzymatic cascade reaction combining Pd-catalyzed C-C formation and enzymatic C=C asymmetric hydrogenation (AH) was developed for enantioselective synthesis of tertiary α-aryl cycloketones in good yields and excellent enantioselectivities. The stereopreference of the enzyme in AH of α-aryl cyclohexenones was studied. An enantiocomplementary enzyme was obtained by site-directed mutation.

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