Spherical polyelectrolyte nanogels as templates to prepare hollow silica nanocarriers: observation by small angle X-ray scattering and TEM

Journal article (2017)

Authors

Haoya Han East China University of Science and Technology
Li Li East China University of Science and Technology
Yuchuan Tian East China University of Science and Technology
Yunwei Wang East China University of Science and Technology
Zhishuang Ye East China University of Science and Technology
Qingsong Yang East China University of Science and Technology
Y. Wang East China University of Science and Technology, ChemE/Advanced Soft Matter - AS
Regine Von Klitzing Technische Universität Darmstadt
Xuhong Guo Shihezi University, East China University of Science and Technology
Research Group
ChemE/Advanced Soft Matter (AS) (TU Delft)
Copyright: © 2017 Haoya Han, Li Li, Yuchuan Tian, Yunwei Wang, Zhishuang Ye, Qingsong Yang, Y. Wang, Regine Von Klitzing, Xuhong Guo
DOI: https://doi.org/10.1039/c7ra10011f
More Info
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Published Date

2017

Language

English

Faculty

Applied Sciences

Department

ChemE/Chemical Engineering

Research Group

ChemE/Advanced Soft Matter

Abstract

Hollow silica nanoparticles were prepared through generating a silica layer in spherical polyelectrolyte nanogels (SPN), which consisted of a solid core of polystyrene (PS) and a shell of crosslinked poly(acrylic acid) (PAA), followed by removing the PS core via solvent dissolution. Small angle X-ray scattering (SAXS) in combination with TEM were employed to observe SPN, silica-polymer composite, and hollow silica nanoparticles. It was confirmed that SAXS is a powerful method to monitor the generation of silica layer in SPN. The density and thickness of generated silica layer in SPN were found to be tunable by controlling the crosslinking density of the templates. The porous structure and pH sensitivity of silica layer allowed the obtained hollow silica to be ideal carriers for controlled drug delivery.