The rates of Cu(ii)-ATCUN complex formation. Why so slow?

Journal article (2022)

Authors

Radosław Kotuniak Polish Academy of Sciences
Paulina Szczerba Polish Academy of Sciences
Dobromiła Sudzik Polish Academy of Sciences
M.J.F. Strampraad BT/Biocatalysis - AS
P.L. Hagedoorn BT/Biocatalysis - AS
Wojciech Bal Polish Academy of Sciences
Research Group
BT/Biocatalysis (AS) (TU Delft)
Copyright: © 2022 Radosław Kotuniak, Paulina Szczerba, Dobromiła Sudzik, M.J.F. Strampraad, P.L. Hagedoorn, Wojciech Bal
DOI: https://doi.org/10.1039/d2dt02856e
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Published Date

2022

Language

English

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Faculty

Applied Sciences

Department

BT/Biotechnologie

Research Group

BT/Biocatalysis

Abstract

We used a series of modified/substituted GGH analogues to investigate the kinetics of Cu(ii) binding to ACTUN peptides. Rules for rate modulation by 1st and 2nd sphere interactions were established, providing crucial insight into elucidation of the reaction mechanism and its contribution to biological copper transport.

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