Chemoenzymatic intermolecular haloether synthesis

Journal article (2022)

Authors

Shaohang Chen Wuhan University of Science and Technology
Jiaan Zhang Wuhan University of Science and Technology
Zhigang Zeng Wuhan University of Science and Technology
Zongjie Dai Chinese Academy of Sciences
Qinhong Wang Chinese Academy of Sciences
Ron Wever Universiteit van Amsterdam
F. Hollmann BT/Biocatalysis - AS
W. Zhang BT/Biocatalysis - AS , Chinese Academy of Sciences
Research Group
BT/Biocatalysis (AS) (TU Delft)
Copyright: © 2022 Shaohang Chen, Jiaan Zhang, Zhigang Zeng, Zongjie Dai, Qinhong Wang, Ron Wever, F. Hollmann, W. Zhang
DOI: https://doi.org/10.1016/j.mcat.2021.112061
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Published Date

2022

Language

English

Faculty

Applied Sciences

Department

BT/Biotechnologie

Research Group

BT/Biocatalysis

Abstract

A chemoenzymatic method for the synthesis of haloethers is presented. A combination of enzymatic hypohalite synthesis with spontaneous oxidation of alkenes and nucleophilic attack by various alcohols enabled the synthesis of a wide range of haloethers. The reaction system has been characterised and current imitations have been worked out. In the present, aqueous reaction system, hydroxyhalide formation represents the main undesired side reaction. Nevertheless, semi-preparative scale synthesis of a range of haloethers is demonstrated.