Numerical simulation of coronary obstruction risk assessment for AVNeo valve after trans-catheter valve replacement with SAPIEN 3 stent

Master thesis (2024)

Authors

Z. Li Mechanical Engineering

Contributors

S. Pirola Medical Instruments & Bio-Inspired Technology - Mechanical, Maritime and Materials Engineering (mentor)

Giulia Luraghi (graduation committee member)

B.F. Fereidoonnezhad Medical Instruments & Bio-Inspired Technology - Mechanical, Maritime and Materials Engineering (graduation committee member)

Faculty

Mechanical Engineering

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Published Date

29-08-2024

Language

English

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Faculty

Mechanical Engineering

Abstract

Trans-catheter aortic valve replacement (TAVR) has been widely used for treating Aortic stenosis (AoS). Numerical simulation of TAVR process is valuable in terms of reducing surgical risk for patients and cost for valve design. Finite element simulations are performed in this thesis to investigate the risk of coronary obstruction for patients who went through Aortic Valve Neo-cuspitization (AVNeo or Ozaki) procedure. The Expected Leaflet-to-ostium Distance was used as a criterion for assessing coronary obstruction risk. This value in 3 different deployment configurations is compared to determine the optimal deployment strategy. It is found that there is a large risk of coronary obstruction after TAVR for such patients under distal and midplane configuration but no risk under proximal configuration.

Files

Zeyang_MSc_R4.pdf

File under embargo until 01-09-2026