Mimicking the nuclear pore complex using nanopores

Doctoral thesis (2018)

Authors

A.N. Ananth BN/Cees Dekker Lab - AS
Research Group
BN/Cees Dekker Lab (AS) (TU Delft)
Copyright: © 2018 A.N. Ananth
DOI: https://doi.org/10.4233/uuid:4f0141e7-9b97-4ed4-86be-9b885b420423
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Published Date

2018

Language

English

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Faculty

Applied Sciences

Department

BN/Bionanoscience

Research Group

BN/Cees Dekker Lab

Abstract

Nuclear pore complexes acts as a gatekeeper for molecular transport between the nucleus and the cytoplasm in eukaryotic cells. The central NPC channel is filled with intrinsically disordered FG domains (phenylalanine (F), glycine (G)) that are responsible for the fascinating selectivity of NPCs, for which the underlying mechanism is still under considerable debate. In this thesis, a minimalistic mimic of (NPCs) was constructed using solid-state nanopore and DNA origami to study the spatial arrangement and transport process.

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