Stability analysis of an artificial biomolecular oscillator with non-cooperative regulatory interactions

Cuba Samaniego, Christian; Giordano, G.; Blanchini, Franco; Franco, Elisa

Stability analysis of an artificial biomolecular oscillator with non-cooperative regulatory interactions

Journal article (2017)

Authors

Christian Cuba Samaniego University of California

G. Giordano Lund University

Franco Blanchini Università degli Studi di Udine

Elisa Franco University of California

Affiliation

External organisation

Molecular biology Nonlinear systems Biochemistry Nonlinear oscillations Biological applications

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Published Date

01-01-2017

Language

English

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Abstract

Oscillators are essential to fuel autonomous behaviours in molecular systems. Artificial oscillators built with programmable biological molecules such as DNA and RNA are generally easy to build and tune, and can serve as timers for biological computation and regulation. We describe a new artificial nucleic acid biochemical reaction network, andwedemonstrate its capacity to exhibit oscillatory solutions. This network can be built in vitro using nucleic acids and three bacteriophage enzymes, and has the potential to be implemented in cells. Numerical simulations suggest that oscillations occur in a realistic range of reaction rates and concentrations.