Synthesis of Enantiopure Vicinal Halohydrins Using a Sequence of Haloperoxidase and Lipase

Journal article (2024)

Authors

Elisa De Marchi Universita degli Studi della Tuscia Viterbo
T. Hilberath BT/Biocatalysis - AS
Claudio Zippilli Universita degli Studi della Tuscia Viterbo
Ron Wever Universiteit van Amsterdam
Raffaele Saladino Universita degli Studi della Tuscia Viterbo
F. Hollmann BT/Biocatalysis - AS
Lorenzo Botta Universita degli Studi della Tuscia Viterbo
Research Group
BT/Biocatalysis (AS) (TU Delft)
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Published Date

2024

Language

English

Faculty

Applied Sciences

Department

BT/Biotechnologie

Research Group

BT/Biocatalysis

Abstract

Vicinal halohydrins are key building blocks to produce bioactive molecules and drugs, especially if they can be obtained in enantiomerically pure form. In this study, we present a bi-enzymatic sequence that allows to obtain vic-halohydrins through a photochemoenzymatic olefin hydroxy halogenation followed by a lipase catalysed kinetic resolution. The absolute configuration of the resulting products was determined using Mosher's method.