Synthetic Biology for Multiscale Designed Biomimetic Assemblies

From Designed Self-Assembling Biopolymers to Bacterial Bioprinting

Journal article (2019)

Authors

Andreja Majerle National Institute of Chemistry, Ljubljana
D.T. Schmieden BN/Marie-Eve Aubin-Tam Lab - AS , Kavli institute of nanoscience Delft
Roman Jerala National Institute of Chemistry, Ljubljana
Anne S. Meyer University of Rochester
Research Group
BN/Marie-Eve Aubin-Tam Lab (AS) (TU Delft)
Copyright: © 2019 Andreja Majerle, D.T. Schmieden, Roman Jerala, Anne S. Meyer
DOI: https://doi.org/10.1021/acs.biochem.8b00922
More Info
expand_more

Published Date

2019

Language

English

Reuse Rights

Other than for strictly personal use, it is not permitted to download, forward or distribute the text or part of it, without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license such as Creative Commons.

Faculty

Applied Sciences

Department

BN/Bionanoscience

Research Group

BN/Marie-Eve Aubin-Tam Lab

Abstract

Nature is based on complex self-assembling systems that span from the nanoscale to the macroscale. We have already begun to design biomimetic systems with properties that have not evolved in nature, based on designed molecular interactions and regulation of biological systems. Synthetic biology is based on the principle of modularity, repurposing diverse building modules to design new types of molecular and cellular assemblies. While we are currently able to use techniques from synthetic biology to design self-assembling molecules and re-engineer functional cells, we still need to use guided assembly to construct biological assemblies at the macroscale. We review the recent strategies for designing biological systems ranging from molecular assemblies based on self-assembly of (poly)peptides to the guided assembly of patterned bacteria, spanning 7 orders of magnitude.

Files

Majerle-et-al-2019-synthetic-b... (pdf)
(pdf | 2.5 Mb)
- Embargo expired in 08-10-2019
Unknown license