A Photochemoenzymatic Hunsdiecker-Borodin-Type Halodecarboxylation of Ferulic Acid

Journal article (2022)

Authors

C. Zippilli BT/Biocatalysis - AS , Universita degli Studi della Tuscia Viterbo
Miguel Jimenez Bartolome Universityof NaturalResourcesand Life Sciences, Vienna
Thomas Hilberath BT/Biocatalysis - AS
Lorenzo Botta Universita degli Studi della Tuscia Viterbo
F Hollmann BT/Biocatalysis - AS
Raffaele Saladino Universita degli Studi della Tuscia Viterbo
Research Group
BT/Biocatalysis (AS) (TU Delft)
Copyright: © 2022 C. Zippilli, Miguel Jimenez Bartolome, T. Hilberath, Lorenzo Botta, F. Hollmann, Raffaele Saladino
DOI: https://doi.org/10.1002/cbic.202200367
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Published Date

2022

Language

English

Faculty

Applied Sciences

Department

BT/Biotechnologie

Research Group

BT/Biocatalysis

Abstract

A photochemoenzymatic halodecarboxylation of ferulic acid was achieved using vanadate-dependent chloroperoxidase as (bio)catalyst and oxygen and organic solvent as sole stoichiometric reagents in a biphasic system. Performance and selectivity were improved through a phase transfer catalyst, reaching a turnover number of 660.000 for the enzyme.