Patient-reported outcome measures (PROMs) in pancreatic cancer

Maharaj, A.D.; Talic, Stella; Evans, Peter; Knowles, Brett; Leong, Trevor; Philip, Jennifer; Smith, Marty; Ioannou, Liane J.; Evans, Sue M.; Zalcberg, John R.; Neale, Rachel E.; Goldstein, David; Merrett, Neil D.; White, Kate; Croagh, Daniel; Pilgrim, Charles H.C.

Patient-reported outcome measures (PROMs) in pancreatic cancer

a systematic review

Review (2020)

Authors

A.D. Maharaj Monash University

Stella Talic Monash University

Peter Evans Monash University

Brett Knowles St. Vincent's Hospital and University of Melbourne, Royal Melbourne Hospital, Peter Maccallum Cancer Centre

Trevor Leong Monash University, University of Melbourne, Peter Maccallum Cancer Centre

Jennifer Philip University of Melbourne, Victorian Comprehensive Cancer Centre, Royal Melbourne Hospital, Peter Maccallum Cancer Centre, St. Vincent's Hospital and University of Melbourne

Marty Smith Cabrini Health, Alfred Health

Liane J. Ioannou Monash University

Sue M. Evans Monash University

John R. Zalcberg Monash University

Rachel E. Neale Queensland Institute of Medical Research

David Goldstein University of New South Wales

Neil D. Merrett Western Sydney University

Kate White University of Sydney

Daniel Croagh Monash University, Epworth HealthCare

Charles H.C. Pilgrim Cabrini Health, Alfred Health, Peninsula Private Hospital, Monash University, Peninsula Health

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Published Date

2020

Language

English

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Abstract

Background: The aim of this systematic review is to examine patient-reported outcome measures (PROMs), their attributes and application in patients with pancreatic cancer (PC). Method: A systematic literature search was undertaken of articles published to June 2018 to identify PROMs applied in primary studies in PC. Characteristics of the included studies and PROMs were described with identified scales grouped into five domains. The psychometric properties of the identified PROMs were further assessed for reliability and validity among patients with PC. Results: From 1688 studies screened, 170 were included. Almost half (48%) were conducted in patients with unresectable PC; the majority of these (68%) were evaluated in randomized controlled trials. Median questionnaire completion rates fell below 10% of the original cohort within 12 months in patients with unresectable PC compared to 75% in patients with resectable PC. Seventy PROMs were identified, 32 measuring unidimensional parameters (e.g. pain) and 35 measuring multidimensional (e.g. quality of life) constructs. Only five (7%) PROMs were disease-specific and 13 (19%) were validated in patients with PC. Fifty scales were grouped into 19 physical, 9 psychological, 6 psychiatric, 9 social and 7 other domains. Conclusion: Three multidimensional PROMs, the: (i) FACT-HEP in unresectable PC; (ii) QLQ-PAN26 (in conjunction with its core QLQ-C30 PROM) in resectable PC; and (iii) MDASI-GI are recommended as instruments to capture quality of life in patients with PC. Summarised scales and psychometric evaluation provide a framework to choose PROMs for scales not captured by the recommended PROMs.