Left ventricular pressure transmission to myocardial lymph vessels is different during systole and diastole

Journal article (1993)

Authors

Y Han Universiteit van Amsterdam
Isabelle Vergroesen Universiteit van Amsterdam
M Goto Universiteit van Amsterdam
J. Dankelman Medical Instruments & Bio-Inspired Technology - Mechanical, Maritime and Materials Engineering
CPB van der Ploeg Erasmus MC, TNO
Jos A.E. Spaan Universiteit van Amsterdam
Research Group
Medical Instruments & Bio-Inspired Technology (Mechanical, Maritime and Materials Engineering) (TU Delft)
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Published Date

1993

Language

English

Reuse Rights

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Faculty

Mechanical, Maritime and Materials Engineering

Department

Biomechanical Engineering

Research Group

Medical Instruments & Bio-Inspired Technology

Abstract

In six open-thorax-anaesthetized dogs with paced hearts and a retrogradely cannulated epicardial lymph vessel, the sensitivity of myocardial lymph pres- sure to left ventricular pressure during systole and during diastole was determined. The lymph vessels were can- nulated using PE-90 tubing, and lymph pressure was measured by connecting the cannula to a microtip press- ure transducer. To obtain the systolic sensitivity, left ven- tricular pressure was changed by clamping the de- scending aorta, which caused left ventricular pressure to increase. The diastolic sensitivity was obtained from natural variation to left ventricular pressure caused by atrial contractions during induced long diastoles. The mean ratio of the pulse in lymph pressure to the pulse in left ventricular pressure was determined: systole: 0.069 + 0.013, n = 213, diastole: 0.76 -+ 0.16, n = 249 and, if possible, linear regression analysis between lymph and left ventricular pressure was performed. The systolic regression coefficients could be determined in six dogs and the diastolic coefficients in three dogs. Dur- ing long diastoles lymph pressure variations are on aver- age 76 per cent of those in the left ventricle. However, during systole, the sensitivity of lymph pressure to left ventricular pressure is more than ten times lower. It is not unlikely that the structural embedment of lymph ves- sels within the myocardium is such that volume vari- ations by cardiac contraction are limited.