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Jungbauer, Alois (author), Satzer, Peter (author), Duerauer, Astrid (author), Azevedo, Ana (author), Aires-Barros, Raquel (author), Nilsson, Bernt (author), Farid, Suzy (author), Goldrick, Stephen (author), Ottens, M. (author)The main objectives of bioprocesses are to reliably deliver drugs in a relatively short time frame with high quality within a tight regulatory framework. Bioprocesses are highly complex, the level of automation is moderate, and there is constant pressure to improve efficiency and costs. In addition, climate change and resource scarcity...review 2024
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Smit, Jelle (author)Organ-on-chip (OoC) technology has transformed biomedical research by providing a platform to simulate physiological conditions for drug development and disease modeling. Incubator-free OoC systems offer notable advantages over traditional approaches, including enhanced adaptability and impermeability to gases. Nevertheless, achieving precise...master thesis 2024
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Spoerer Ruiz-Tagle, Sebastián (author)This project explores the integration of a microfluidic system within the MedRing device, aimed at enhancing women’s health monitoring by non-invasively tracking fertility-related biomarkers. The primary goal is to leverage MedRing’s capabilities to provide real-time, accurate health insights, thereby contributing to the advancement of...master thesis 2024
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Kawasaki, S. (author)CMUTs (Capacitive Micromachined Ultrasonic Transducers) are causing a technological revolution. Research over the last decade showed that CMUTs can sufficiently replace traditional ultrasound technology based on the bulk PZT, along with other benefits such as lower assembly cost, broader bandwidth and monolithic integration capability with ASICs...doctoral thesis 2024
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Wassenaar, Maurits (author)Mechanical forces are integral to the functionality and behavior of biological systems, from the cellular to the molecular level. Acoustic force spectroscopy (AFS), an emerging field, seeks to explore these intricate dynamics. Traditional methods in AFS, particularly those using bulk acoustic wave (BAW) devices, still lack sample visibility and...master thesis 2023
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Singh, Sampuran (author)Small satellites require efficient propulsion systems for attitude and orbit control. This thesis focuses on the development and characterization of two distinct types of micro-resistojet thrusters, namely Vaporizing Liquid Micro-resistojet (VLM) and Low Pressure Micro-resistojet (LPM). Both concepts are developed at TU Delft and are designed to...master thesis 2023
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Neves Sao Pedro, M. (author)Continuous biomanufacturing is considered the future phase for the optimization of production processes in the biopharmaceutical industry. Productivity, product quality and consistency are greatly improved while production costs and environmental footprint are drastically reduced. The manufacturing of monoclonal antibodies (mAbs), an important...doctoral thesis 2023
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Tjokro, Kristie (author)In microfluidics, typical laboratory processes can be condensed to a miniature device. This reduces analysis time and required volumes of samples and reagents, increases mobility and flexibility, and is cost effective. In this work, the environmental impacts of three microfluidic devices for glucose detection are assessed using a comparative...master thesis 2023
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Dubbelman, Thomas (author)Crystallization is one of the most common separation techniques in chemical industry. Nonetheless, the nucleation step in the crystallization process is little understood. This makes it difficult to gain control over the crystallization process and more specifically crystal properties. Nucleation mechanics is therefore studied thoroughly. Non...master thesis 2023
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Motreuil-Ragot, P.A. (author)An organ-on-chip (OoC) is a microelectromechanical (MEMS) device that aims to recapitulate in-vitro the physiology of the smallest functional unit of an organ in order to perform drug analysis or study disease models. OoCs are very complex systems that require actuation and sensing capabilities within controlled and delicate environment. The...doctoral thesis 2023
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Struijk, Victor (author)Life at low-Reynolds numbers regime is intriguing. Single motile bacteria are known to exhibit erratic behaviour; they swim in what is known as a random walk, alternating between periods of swimming straight and abrupt moments of re-orientation. Yet in dense populations, cells of E.coli have been reported to exhibit weak synchronization and self...master thesis 2023
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Waling, Loulotte (author)In recent years, biotechnological processes have gained increased interest due to their potential for high-value compound production and waste recycling. This shift towards biotechnology is driven by global challenges such as food security, climate change, and the transition to renewable resources. To address the limitations of large-scale...master thesis 2023
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Braem, Sarah (author)Drug efficacy and side effects are significantly impacted by the first-pass metabolism, a sequence of events that occurs in the stomach and the liver after oral ingestion. Accurate prediction of this mechanism is crucial for a faster and more cost-efficient drug development process. Replicating the first-pass metabolism in vitro using standard...master thesis 2023
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Dutta, S. (author), Bieling, T.J. (author), Verbiest, G.J. (author)Fluid flow processes such as drainage and evaporation in porous media are crucial in geological and biological systems. The motion of the displacement front of a moving fluid through multi-phase interfaces is often associated with abrupt mechanical energy release, detectable as acoustic emissions (AEs). The exact origin of these pulses and...journal article 2023
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Tsan, Vi hung (author), Fan, D. (author), Caneva, S. (author), Smith, C.S. (author), Verbiest, G.J. (author)A low-cost glass-based microfluidic flow cell with a piezo actuator is built using off-the-shelf parts (total cost €9 per device) to apply acoustophoretic force on polystyrene micro-beads. The main challenge in the fabrication of these devices was to ensure their leak tightness, which we solved using double-sided tape and nail polish. Beads...journal article 2023
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Neves Sao Pedro, M. (author), Isaksson, Madelène (author), Gomis-Fons, Joaquín (author), Eppink, Michel H.M. (author), Nilsson, Bernt (author), Ottens, M. (author)The implementation of continuous processing in the biopharmaceutical industry is hindered by the scarcity of process analytical technologies (PAT). To monitor and control a continuous process, PAT tools will be crucial to measure real-time product quality attributes such as protein aggregation. Miniaturizing these analytical techniques can...journal article 2023
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Bazyar, H. (author)Microfluidic technology is a powerful tool to enable the rapid, accurate, and on-site analysis of forensically relevant evidence on a crime scene. This review paper provides a summary on the application of this technology in various forensic investigation fields spanning from forensic serology and human identification to discriminating and...review 2023
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Kurniawan, Tetuko (author), Sahebdivani, Mahsa (author), Zaremba, Damian (author), Blonski, Slawomir (author), Garstecki, Piotr (author), van Steijn, V. (author), Korczyk, Piotr M. (author)Two decades of research on droplet formation in microchannels have led to the widely accepted view that droplets form through the squeezing mechanism when interfacial forces dominate over viscous forces. The initially surprising finding that the volume of the droplets is insensitive to the relative importance of these two forces is nowadays...journal article 2023
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Blankespoor, Maarten (author), Manzaneque Garcia, T. (author), Ghatkesar, M.K. (author)The capacity to precisely pipette femtoliter volumes of liquid enables many applications, for example, to functionalize a nanoscale surface and manipulate fluids inside a single-cell. A pressure-controlled pipetting method is the most preferred, since it enables the widest range of working liquids. However, precisely controlling femtoliter...journal article 2023
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Trapp, S. (author), Lammers, Tom (author), Engudar, Gokce (author), Hoehr, Cornelia (author), Denkova, A.G. (author), Paulssen, E. (author), de Kruijff, R.M. (author)Background: The radionuclide Ga-68 is commonly used in nuclear medicine, specifically in positron emission tomography (PET). Recently, the interest in producing Ga-68 by cyclotron irradiation of [<sup>68</sup>Zn]Zn nitrate liquid targets is increasing. However, current purification methods of Ga-68 from the target solution consist of multi...journal article 2023