Computational modeling and optimization of biopharmaceutical downstream processes

Vaccination is a strong and effective way to prevent spreading of infectious diseases and promotes global health. In the future, the importance of vaccines is expected only to increase, driven by factors such as increased international traveling, higher healthcare expenditures, and a growing population. To meet the growing demands, it is...

Efficient Embedded Element Pattern Prediction via Machine Learning: A Case Study with Planar Non-Uniform Sub-Arrays

Efficient prediction of embedded element patterns (EEPs) is including the mutual coupling (MC) effects in the optimization of irregular planar arrays is studied for the first time in the literature. An ANN-based methodology is used to predict the pattern of each element in the whole visible space for a flexible planar array topology in...

Physically recurrent neural networks for path-dependent heterogeneous materials: Embedding constitutive models in a data-driven surrogate

Driven by the need to accelerate numerical simulations, the use of machine learning techniques is rapidly growing in the field of computational solid mechanics. Their application is especially advantageous in concurrent multiscale finite element analysis (FE²) due to the exceedingly high computational costs often associated with it...

Acoustic emission source location using Lamb wave propagation simulation and artificial neural network for I-shaped steel girder

Acoustic emission (AE) is often used for structural health monitoring (SHM) in the wide field of engineering structures and one of its most beneficial attributes is the ability to localize the damage/crack based on the AE events. The vast majority of ongoing work on AE monitoring focues on geometrically simple structures or a confined area,...

Comparison of Data-driven Prognostics Models: A Process Perspective

Remaining useful life (RUL) prediction is crucial for the implementation of Prognostics and Health Management (PHM) systems, enabling application of predictive maintenance strategies for critical systems (e.g. in aviation, power, railway). Existing literature addresses aspects of data-driven prognostic approaches, with a predominant focus on...