Title
Organ-on-Silicon
Author
Gaio, N. (TU Delft Electronic Components, Technology and Materials) 
Contributor
Dekker, R. (promotor)
Degree granting institution
Delft University of Technology
Date
2019-07-12
Abstract
The cost and the development time of pharamecutical products are often severely affected by the in vitro tests currently employed in pharmaceutical R&D. These assays are often failing to accurately recapitulate diseases and to predict human responses to new medicines. Organ-on-Chip (OOC) devices are designed to result in advanced in vitro assays that better replicate human responses. The increasing interest and demand for this new class of devices is pushing for a quick commercialization of these tools. However, the currently employed fabrication processes pose major technical hurdles towards large-scale manufacturing, higher throughput and robustness, which are important steps for industrial adoption. This thesis aims to address these challenges, by implementing conventional cleanroom-compatible microfabrication processes for their fabrication. The aim is to copy, in the OOC field, what has been done in the microelectro- mechanical system (MEMS) field, where the standardization of surface patterning techniques using lithography and etching have been a major factor in their success. The OOCs resulting from this effort are named Organ-on-Silicon (OOS) devices in this thesis...
Subject
Organ-on-Chip
Organ-on-Silicon
Polymer
silicon
platform
microelectrode array
packaging
system
heart
brain
To reference this document use:
https://doi.org/10.4233/uuid:ceba7976-a4b0-469e-bdd0-70f0a14dc275
ISBN
978-94-028-1575-7
Embargo date
2025-07-12
Part of collection
Institutional Repository
Document type
doctoral thesis
Rights
© 2019 N. Gaio