Title
From Short Circuit to Completed Circuit: Conductive Hydrogel Facilitating Oral Wound Healing
Author
Zhou, Qiangqiang (Fudan University)
Dai, Hanqing (Fudan University)
Yan, Yukun (Fudan University)
Qin, Zhiming (Fudan University)
Zhou, Mengqi (Fudan University)
Zhang, Wanlu (Fudan University)
Zhang, Kouchi (TU Delft Electronic Components, Technology and Materials) 
Guo, Ruiqian (Fudan University)
Wei, X. (Fudan University)
Date
2024
Abstract
The primary challenges posed by oral mucosal diseases are their high incidence and the difficulty in managing symptoms. Inspired by the ability of bioelectricity to activate cells, accelerate metabolism, and enhance immunity, a conductive polyacrylamide/sodium alginate crosslinked hydrogel composite containing reduced graphene oxide (PAA-SA@rGO) is developed. This composite possesses antibacterial, anti-inflammatory, and antioxidant properties, serving as a bridge to turn the “short circuit” of the injured site into a “completed circuit,” thereby prompting fibroblasts in proximity to the wound site to secrete growth factors and expedite tissue regeneration. Simultaneously, the PAA-SA@rGO hydrogel effectively seals wounds to form a barrier, exhibits antibacterial and anti-inflammatory properties, and prevents foreign bacterial invasion. As the electric field of the wound is rebuilt and repaired by the PAA-SA@rGO hydrogel, a 5 × 5 mm2 wound in the full-thickness buccal mucosa of rats can be expeditiously mended within mere 7 days. The theoretical calculations indicate that the PAA-SA@rGO hydrogel can aggregate and express SOX2, PITX1, and PITX2 at the wound site, which has a promoting effect on rapid wound healing. Importantly, this PAA-SA@rGO hydrogel has a fast curative effect and only needs to be applied for the first three days, which significantly improves patient satisfaction during treatment.
Subject
conductive hydrogel
microphysiological electric field
oral mucosal disease
tissue regeneration
To reference this document use:
http://resolver.tudelft.nl/uuid:a097ae29-f9c3-4629-87f0-49c037cdec52
DOI
https://doi.org/10.1002/adhm.202303143
Embargo date
2024-08-02
ISSN
2192-2640
Source
Advanced Healthcare Materials
Bibliographical note
Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.
Part of collection
Institutional Repository
Document type
journal article
Rights
© 2024 Qiangqiang Zhou, Hanqing Dai, Yukun Yan, Zhiming Qin, Mengqi Zhou, Wanlu Zhang, Kouchi Zhang, Ruiqian Guo, X. Wei