Print Email Facebook Twitter The multi-dimensional challenges of controlling respiratory virus transmission in indoor spaces Title The multi-dimensional challenges of controlling respiratory virus transmission in indoor spaces: Insights from the linkage of a microscopic pedestrian simulation and SARS-CoV-2 transmission model Author Balkan, Büsra Atamer (Wageningen University & Research) Chang, You (Wageningen University & Research) Sparnaaij, M. (TU Delft Transport and Planning) Wouda, B.J. (TU Delft Game Lab) Boschma, D. (TU Delft Game Lab) Yuan, Y. (TU Delft Transport and Planning) Daamen, W. (TU Delft Transport and Planning) van Veen, A.J. (TU Delft Game Lab) Duives, D.C. (TU Delft Transport and Planning) Date 2024 Abstract SARS-CoV-2 transmission in indoor spaces, where most infection events occur, depends on the types and duration of human interactions, among others. Understanding how these human behaviours interface with virus characteristics to drive pathogen transmission and dictate the outcomes of non-pharmaceutical interventions is important for the informed and safe use of indoor spaces. To better understand these complex interactions, we developed the Pedestrian Dynamics—Virus Spread model (PeDViS): an individual-based model that combines pedestrian behaviour models with virus spread models that incorporate direct and indirect transmission routes. We explored the relationships between virus exposure and the duration, distance, respiratory behaviour, and environment in which interactions between infected and uninfected individuals took place and compared this to benchmark ‘at risk’ interactions (1.5 metres for 15 minutes). When considering aerosol transmission, individuals adhering to distancing measures may be at risk due to build-up of airborne virus in the environment when infected individuals spend prolonged time indoors. In our restaurant case, guests seated at tables near infected individuals were at limited risk of infection but could, particularly in poorly ventilated places, experience risks that surpass that of benchmark interactions. Combining interventions that target different transmission routes can aid in accumulating impact, for instance by combining ventilation with face masks. The impact of such combined interventions depends on the relative importance of transmission routes, which is hard to disentangle and highly context dependent. To reference this document use: http://resolver.tudelft.nl/uuid:2e40617a-6799-4465-9198-593821b408cd DOI https://doi.org/10.1371/journal.pcbi.1011956 ISSN 1553-734X Source PLoS Computational Biology (Print), 20 (3) Part of collection Institutional Repository Document type journal article Rights © 2024 Büsra Atamer Balkan, You Chang, M. Sparnaaij, B.J. Wouda, D. Boschma, Y. Yuan, W. Daamen, A.J. van Veen, D.C. Duives, More Authors Files PDF journal.pcbi.1011956-1.pdf 4.18 MB Close viewer /islandora/object/uuid:2e40617a-6799-4465-9198-593821b408cd/datastream/OBJ/view